Swimming Euglena respond to confinement with a behavioural change enabling effective crawling

TitleSwimming Euglena respond to confinement with a behavioural change enabling effective crawling
Publication TypeJournal Article
Year of Publication2019
AuthorsNoselli G, Beran A, Arroyo M, DeSimone A
JournalNature Physics
Volume15
Pagination496-502
Keywordscrawling motility, Euglena gracilis, Metaboly, Spatial confinement
Abstract

Some euglenids, a family of aquatic unicellular organisms, can develop highly concerted, large-amplitude peristaltic body deformations. This remarkable behaviour has been known for centuries. Yet, its function remains controversial, and is even viewed as a functionless ancestral vestige. Here, by examining swimming Euglena‚ÄČgracilis in environments of controlled crowding and geometry, we show that this behaviour is triggered by confinement. Under these conditions, it allows cells to switch from unviable flagellar swimming to a new and highly robust mode of fast crawling, which can deal with extreme geometric confinement and turn both frictional and hydraulic resistance into propulsive forces. To understand how a single cell can control such an adaptable and robust mode of locomotion, we developed a computational model of the motile apparatus of Euglena cells consisting of an active striated cell envelope. Our modelling shows that gait adaptability does not require specific mechanosensitive feedback but instead can be explained by the mechanical self-regulation of an elastic and extended motor system. Our study thus identifies a locomotory function and the operating principles of the adaptable peristaltic body deformation of Euglena cells.

DOI10.1038/s41567-019-0425-8